Revised SPC: Truvada (tenofovir disoproxil fumarate/emtricitabine) tablets

SPC does not recommend co-administration of tenofovir disoproxil and didanosine due to increased systemic exposure (40-60%) to didanosine which may increase didanosine-related adverse reactions. Co-administration has also associated with a significant decrease in CD4 cell count.

Source:

electronic Medicines compendium