Revised SPCs: Imbruvica (ibrutinib) tablets – all strengths

SPC now notes a single 560 mg dose does not have a clinically meaningful effect on exposure of midazolam. Two weeks treatment with 560 mg daily has no effect on pharmacokinetics of oral contraceptives, midazolam, nor the CYP2B6 substrate bupropion.

Source:

electronic Medicines compendium