Revised SPCs: Imbruvica (ibrutinib) tablets – all strengths

SPC now notes a single 560 mg dose does not have a clinically meaningful effect on exposure of midazolam. Two weeks treatment with 560 mg daily has no effect on pharmacokinetics of oral contraceptives, midazolam, nor the CYP2B6 substrate bupropion.


electronic Medicines compendium