Revised SPCs: Tecfidera (dimethyl fumarate) 120 and 240mg gastro-resistant hard capsules
SPCs updated to warn that cases of Fanconi syndrome have been reported for dimethyl fumarate products in combination with other fumaric acid esters. Early diagnosis & discontinuation are important to prevent onset of renal impairment and osteomalacia, as it is usually reversible.
Source:
electronic Medicines compendium
SPS commentary:
Fanconi syndrome is a defect of proximal tubule leading to malabsorption of various electrolytes and substances that are usually absorbed by the proximal tubule.