Revised SPCs: Ziagen (abacavir sulfate) – all products

In vitro study showed concomitant administration of single dose of riociguat (0.5 mg) to HIV patients receiving combination of abacavir/dolutegravir/lamivudine (600mg/50mg/300mg once daily) led to approx 3-fold higher riociguat levels. Riociguat dose may need to be reduced.

Source:

electronic Medicines compendium