Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: A population‐based nested case–control study

This study (393 cases, 1494 controls) found among new DOAC users, concurrent use of antiplatelets (adjusted odds ratio 2.01; 95% CI 1.29–3.11) and SSRIs (1.68; 1.10–2.59) was associated with increased risk of major bleeding. Pharmacokinetic interacting drugs did not increase risk


British Journal of Clinical Pharmacology