Safety and Efficacy of Checkpoint Inhibition in Patients With Melanoma and Preexisting Autoimmune Disease: A Cohort Study

Study (n=228) found incidence of immune-related adverse events (irAEs; >/= grade 3) did not differ between pts with and without autoimmune disease (AID). However anti–PD1 induced colitis more frequent in IBD pts (6/31=19%) vs pts with other AIDs (3%) & without AID (2%).

Annals of Internal Medicine