Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

This German study (n=118) of adults with episodic cluster headaches found prednisone (100mg oral for 5 days followed by tapering of 20 mg every 3 days) was associated with a reduction in the number of attacks within the first week (mean 7.1 vs 9.5 with placebo; p=0.002).

Source:

The Lancet Neurology