Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction

Study of 806 children at risk for asthma (AS) found no effect of maternal vitamin D supplementation on 6-year incidence of AS and recurrent wheeze in intention-to-treat analysis or analysis with stratification according to the maternal 25-hydroxyvitamin D level during pregnancy.

SPS commentary:

An editorial discusses what practical conclusions can be derived from these results. It suggests that although supplementation in the trial was not effective in preventing school-age asthma, vitamin D supplementation during pregnancy may still play a role in averting less persistent forms of wheezing in infants with a parental history of asthma and allergies, but further studies are needed to assess this.


New England Journal of Medicine

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