The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

The age-standardised incidence of oesophageal cancer in 2017 was 5.9 (5.7-6.1) and mortality was 5.5 (5.3–5.6) per 100,000 population; both decreased from 1990. Globally a large proportion of DALYs were due to smoking, alcohol, high BMI, diet low in fruits and chewing tobacco.

SPS commentary:

A related Comment notes that a major limitation of this study is its inability to clearly demarcate between oesophageal adenocarcinoma and oesophageal squamous cell carcinoma, which have distinct biology and management approaches, and differing global distribution, risk factors, and temporal changes. The analysis shows the impact of modifiable risk factors on the global burden of oesophageal cancer, which present clear public health issues to be addressed. 


Lancet Gastroenterology and Hepatology

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