The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial

Review of data from the ADVANCE trial (n=11,140) found the effect of intensive glucose treatment on major macro- and microvascular events was reduced in the frail (HR vs standard glucose control = 1.03, [95%CI 0.90-1.19] in the frail, vs 0.84 [0.74-0.94] in the non-frail).

Diabetes Care