The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial

RCT (n=185) found that systolic and diastolic heart function, measured via left ventricular ejection fraction and ratio between mitral peak velocity of early filling to early diastolic mitral annular velocity, did not differ for levothyroxine vs placebo.

The American Journal of Medicine