Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)

Study (n=4,661) found initiation of colchicine < day 3 after myocardial infarction reduced a composite cardiovascular end point vs placebo after a median follow up of 22.7 months (HR 0.52, 95%CI 0.32-0.84), though initiation from day 4 onwards was not superior to placebo.

European Heart Journal