Towards safer risperidone prescribing in Alzheimer's disease

Model showed age-related reduction in risperidone clearance, reduced renal elimination of 9-OH-risperidone (9OR) and slower active moiety clearance in 22% patients. Higher trough 9-OR and active moiety concentrations & lower MMSE scores were linked to extrapyramidal side-effects.

British Journal of Psychiatry