Tramacet 37.5 mg/ 325 mg (tramadol with paracetamol) film-coated tablets and effervescent tablets

Section 4.4 advises “Opioids can cause sleep-related breathing disorders including central sleep apnoea (CSA) and sleep-related hypoxaemia (risk of CSA increased in dose-dependent fashion). In patients who present with CSA, consider decreasing the total opioid dosage.”


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