Trial of Roflumilast Cream for Chronic Plaque Psoriasis

RCT (n=331) found once daily roflumilast cream superior to vehicle in achieving state of clear or almost clear skin based on IGA score at 6 weeks (28% roflumilast 0.3%, 23% roflumilast 0.15%, and 8% vehicle group; p<0.001 and p=0.004 vs. vehicle for 0.3% and 0.15%, respectively).


New England Journal of Medicine