Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

Review (34 studies, n=6974) found treatment with ursodeoxycholic acid (UA) had no significant effect on prevalence of stillbirth in this population vs no treatment with UA (0.7% vs 0.6%). If reviewing only RCT’s, UA was linked to a reduction in stillbirth and preterm birth.