Use of dornase alfa in the paediatric intensive care unit: current literature and a national cross-sectional survey

Survey found high off label use in Dutch PICUs (42% reported prescribing≥ 1 times week) but only 4% reported access to local protocol; and systematic review noted limited evidence base (single RCT, reporting reduced duration of mechanical ventilation by ~ 1 day vs. normal saline)

European Journal of Hospital Pharmacy