Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial

Data from this RCT (n=185) do not support combining neoadjuvant pembrolizumab with chemoradiotherapy after FOLFOX treatment of locally advanced rectal cancer, based on the mean neoadjuvant rectal score difference (11.53 vs 14.08 control arm).

Source:

JAMA Oncology