Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

Review of 46 RCTs (n=75,541) found a lower proportion of participants receiving vitamin D supplementation had acute respiratory tract infections vs placebo (61.3% vs 62.3%, OR 0.92, 95%CI 0.86-0.99). Authors highlight the relevance of these findings to COVID-19 is unknown.

SPS commentary:

A related commentary concludes this updated meta-analysis adds to the existing evidence that vitamin D supplementation can prevent acute respiratory infections, however, the effect is small.  The small effects of vitamin D supplementation on acute respiratory infections cannot yet be expanded to COVID-19, but randomised controlled trials are underway.

Source:

The Lancet Diabetes & Endocrinology

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